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  5. SUMOylation of IQGAP1 promotes the development of colorectal cancer

SUMOylation of IQGAP1 promotes the development of colorectal cancer

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户：soar
【摘 要】
：
IQGAP1 is a conserved multifunctional protein implicated in tumorigenesis.An aberrant expression of IQGAP1 widely exists in many cancers,but the SUMOylation modification of IQGAP1 in carcinogenesis is
【作 者】
：
Yanfang Yang Ziwei Liang Yu He Xixi Wang Shufang Liang 
【机 构】
：
State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,Sichuan University,and Coll
【出 处】
：
中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议
【发表日期】
：
2018年10期
【关键词】
：
IQGAP1 colorectal carcinoma SUMOylation SUMO1 
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　　IQGAP1 is a conserved multifunctional protein implicated in tumorigenesis.An aberrant expression of IQGAP1 widely exists in many cancers,but the SUMOylation modification of IQGAP1 in carcinogenesis is unknown by now.Here we first time explore biological functions of IQGAP1 SUMOylation in promoting colorectal cancer progression in vitro and in vivo.
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