七鳃鳗富含半胱氨酸分泌蛋白PR-1及CRD结构域抗血管新生功能研究

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户：aiyouxizhiwojian

【摘要】

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【作者】

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段丹丹王红艳周蓉姜琪肖蓉

【机构】

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辽宁师范大学,大连,116081

【出处】

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中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议

【发表日期】

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2018年10期

【关键词】

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七鳃鳗口腔腺 CRBGP PR-1 抗血管新生

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　　七鳃鳗口腔腺富含半胱氨酸分泌蛋白(cysteine-rich buccal gland protein,CRBGP)由PR-1(pathogenesisrelatedgroup 1 domain)和CRD(cysteine-rich domain)结构域组成,并具有抗血管新生活性.为深入阐明CRBGP各结构域与其抗血管新生活性的关系,本研究获得了重组结构域蛋白：rL-PR-1和rL-CRD.其中,rL-PR-1能够以剂量依赖性的方式显著抑制人脐静脉内皮细胞(human umbilical vein endothelial cells,HUVECs)的增殖,其IC50为2 μM.

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七鳃鳗富含半胱氨酸分泌蛋白PR-1及CRD结构域抗血管新生功能研究

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