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The convenient derivatization method of amino acid esters as 9-anthraldimine Schiff base derivatives for enantiomer resolution was developed.The corresponding 9-anthraldehyde derivatives of α-amino acid esters were readily synthesized by stirring the α-amino acid ester hydrochloride salts with 9-anthraldehyde in the presence of 1,8-diazabicyclo [5.4.0]undec-7-ene as a base and anhydrous MgSO4.And the liquid chromatographic enantiomer separation of amino acid esters as 9-anthraldimine derivatives was investigated on several coated and covalently bonded polysaccharide-derived chiral stationary phases (CSPs).It was observed that the performance of coated type CSPs was superior to that of covalently bonded type CSPs.