PRELP Activates Osteoblast Mineralization in Mouse PreosteoblasticMC3T3-E1 Cells by the Wnt Signal T

• 作 者: LIHai-Yin[1]CUIYa-Zhou[1]LICheng-Zhi[1]WANGHua-Xin[2]LUANJing[1]ZHOUXiao-Yan[1]HANJin-Xiang[3]
• 机 构: Key Laboratory for Rare Disease Research of Shandong Province,Key Laboratory for Biotech Drugs of th
• 出 处: 第五届泛环渤海生物化学与分子生物学会学术交流会
• 发表日期: 2015年期

　　PRELP is a glycosaminoglycan and collagen binding anchor protein highly expressed in cartilage,basement membranes,and developing bone,it plays an important role in osteoclastogenesis,however,the effect of PRELP on the differentiation of pre-osteoblastic cell line and the related mechanism has not been reported.Herein,we fist found that the expression of PRELP was up-regulated upon stimulation of mineralization in MC3T3-E1 cells.