NFATc3 exerts anti-viral and anti-tumor dual function in hepatitis B virus-related hepatocellular ca

来源 :第十一届全国病毒学学术研讨会暨第六届武汉现代病毒学国际研讨会 | 被引量 : 0次 | 上传用户：whoelse

【摘要】

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Purpose:This study aimed to explore the aberrant status of innate immune response-related gene NFATc3 and its potential function in HBV-related hepatocellular c

【作者】

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Xiangmei Chen Jin Cheng Fengmin Lu

【机构】

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DepartmentofMicrobiology,SchoolofBasicMedicine,PekingUniversityHealthScienceCenter,Beijing,China

【出处】

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第十一届全国病毒学学术研讨会暨第六届武汉现代病毒学国际研讨会

【发表日期】

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2015年10期

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Purpose:This study aimed to explore the aberrant status of innate immune response-related gene NFATc3 and its potential function in HBV-related hepatocellular carcinoma(HCC).Methods:Real-time PCR was used to determine the mRNA level of NFATc3 in HCC samples.The transcriptional regulation of IFN-related genes by NFATc3 was detected by luciferase reporter assay and real-time PCR.The anti-HBV function of NFATc3 was evaluated in vitro and in vivo.CCK-8 assay,wound healing,and transwell assay were used to determine the effect of NFATc3 on HCC oncogenic properties.

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NFATc3 exerts anti-viral and anti-tumor dual function in hepatitis B virus-related hepatocellular ca

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