New insights from pathogen infection-induced inflammation related hepatocellular carcinoma

来源 :第十一届全国病毒学学术研讨会暨第六届武汉现代病毒学国际研讨会 | 被引量 : 0次 | 上传用户：xixihahawotiana

【摘要】

：

Hepatocellular carcinoma (HCC) is frequently linked with pathogen infection-induced chronic inflammation.This study demonstrated that the tumour suppressor seri

【作者】

：

Weiyun Li Jun Xiao Xin Zhou Ming Xu Chaobo Hu Xiaoyan Xu Yao Lu Chang Liu Shengjie Xue Lei Nie Haibin Zhang Zhiqi Li Yanbo Zhang Fu Ji Lijian Hui Wufan Tao Bin Wei Hongyan Wang

【机构】

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InstituteofShanghaiInstituteofBiochemistryandCellBiology(SIBCB),ChineseAcademyofSciences,Renjihospit

【出处】

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第十一届全国病毒学学术研讨会暨第六届武汉现代病毒学国际研讨会

【发表日期】

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2015年10期

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Hepatocellular carcinoma (HCC) is frequently linked with pathogen infection-induced chronic inflammation.This study demonstrated that the tumour suppressor serine/threonine-protein kinase 4 (STK4) dampened TLR4/9-induced proinflammatory cytokine secretion but enhanced TLR3/4 mediated IFN-β production via binding to and phosphorylating IRAK1,leading to IRAK1 degradation.

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New insights from pathogen infection-induced inflammation related hepatocellular carcinoma

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