【摘 要】
：
Melanoma is an aggressive cancer, which is more prevalent among the white-skinned individuals.Apart from the skin;primary melanomas can involve the sites such as the mucosa eye and the leptomeninges.T
【机 构】
：
Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) India
【出 处】
：
BITs 3rd Annual World Cancer Congress-2012(2012第五届世界癌症大会)
论文部分内容阅读
Melanoma is an aggressive cancer, which is more prevalent among the white-skinned individuals.Apart from the skin;primary melanomas can involve the sites such as the mucosa eye and the leptomeninges.The tumor can metastasize to the lymph nodes, lungs, liver and the various other sites.Imaging techniques such as the computed tomography (CT) scan, magnetic resonance imaging (MRI) and the positron emission tomography (PET) scan are used in the staging work-up of patients with melanoma.The tissue-diagnosis is of paramount importance in the clinical management of patients with melanoma, and the histologic examination plays the major role in it.However, the role of various cytologic techniques has also been stressed in diagnosing metastatic and recurrent melanomas;of which the fine needle aspiration cytology (FNAC) is the front runner.Studies have stressed on the role of ultrasound (US) examination and FNA as a potential cost effective alternative to sentinel lymph node biopsy.Significantly, molecular and cytogenetic studies performed on FNA as well as the exfoliative cytologic samples have also been on record.Histologically,melanoma is a highly versatile tumor mimicking a wide range of epithelial and mesenchymal malignancies and this versatility is reflected on cytologic materials as well.This emphasizes need for an utmost care, whilst, pathologically evaluating melanomas, in particular, the amelanotic ones.In difficult situations, immunomarkers such as Melan-A,HMB-45 and S-100 play a critical role in resolving the diagnostic issues;assisting the proper management of patients with melanoma.In the present talk, I will be sharing our institute-experience with respect to the role of FNAC in the diagnosis of metastatic and recurrent melanomas.
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