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Current treatment of prostate cancer includes surgery, radiation therapy, and hormone therapy.These methods are only effective for some patients but with strong side effects, such as much reduced sexual desire or performance.Natural substances such as polymethoxyflavones (PMFs) found in citrus peels possess strong anti-cancer properties.In the global market, there are a few products derived from citrus peel extracts.However, the potential health application of a citrus peel product from Miyauchi Citrus Research Center of Japan has prompted investigation into its efficacy in prevention and treatment of prostate cancer.We have found that the natural compounds from citrus peel can effectively prevent the tumor growth at a lower dose and also effectively shrink or eliminate the tumor at higher dose in a nude mice xenograph model.In this conference, we will also report some human data of how the citrus compounds reduce and cure prostate cancer in an extremely efficient manner.The anti-cancer activity of citrus peel compounds both in vitro and in vivo will be described in this presentation.