【摘 要】
：
Background: Although S-1 plus cisplatin (SP) therapy is recognized as the standard treatment for advanced gastric cancer (AGC) in Japan, its safety and efficacy in elderly patients have not yet been i
【机 构】
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Division of Gastrointestinal Oncology Shizuoka Cancer Center Japan
【出 处】
：
BITs 3rd Annual World Cancer Congress-2012(2012第五届世界癌症大会)
论文部分内容阅读
Background: Although S-1 plus cisplatin (SP) therapy is recognized as the standard treatment for advanced gastric cancer (AGC) in Japan, its safety and efficacy in elderly patients have not yet been investigated sufficiently.Methods: We retrospectively reviewed the data of 58 patients with AGC selected from 82 consecutive patients who were >70 years and were treated with SP or S-1 monotherapy.Patient selection criteria were as follows: unresectable or recurrent disease, adequate organ functions and oral intake, and no prior chemotherapy.In SP, S-1 (40 mg/m2/day,bid) was administered for 3 weeks and cisplatin (60 mg/m2) on day 8, repeated every 5 weeks.In S-1 monotherapy,S-1 (40 mg/m2/day, bid) was administered for 4 weeks, repeated every 6 weeks.Results: SP and S-1 was administered in 21 and in 37 patients, respectively.There were some differences in the patient background between the SP group and the S-1 group, such as patients of>76 years (19% and 32%,p =0.27), intestinal type carcinoma (48% and 62%, p =0.28), and presence of peritoneal metastasis (14% and 43%, p =0.04).Median progression-free survival time, and median survival time in SP and S-1 groups were 5.0 and 5.2 months (hazard ratio:1.18), and 14.4 and 10.9 months (hazard ratio: 0.98), respectively.The incidence of grade 3/4 hematological toxicities was higher in the SP than in the S-1 group (57% and 35%,p =0.17).Conclusion: Superiority of SP therapy over S-1 monotherapy was not prominent in elderly patients.
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