【摘 要】
：
Living organisms on the earth are exposed to the geomagnetic field(GMF)during the evolution history.Elimination of the GMF,called hypogeomagnetic field(HMF),leads to central nervous system dysfunction
【机 构】
：
State Key Laboratory of Brain and Cognitive Science,Institute of Biophysics,Chinese Academy of Scien
【出 处】
：
第九届海内外华人神经科学家研讨会(The 9th Symposium for Chinese Neuroscientis
论文部分内容阅读
Living organisms on the earth are exposed to the geomagnetic field(GMF)during the evolution history.Elimination of the GMF,called hypogeomagnetic field(HMF),leads to central nervous system dysfunction and abnormal development in animals.However,the cellular mechanism underlying these effects has not been identified so far.Here,we show that exposure to an HMF(< 200 nT),produced by a magnetic field shielding chamber,promotes the proliferation of neural progenitor/stem cells(NPCs/NSCs)from C57BL/6 mice.Following seven-day HMFexposure,the primary neurospheres(NSs)were significantly larger in size and twice more NPCs/NSCs were harvested from neonatal NSs,when compared to the GMF controls.The selfrenewal capacity and multipotency of the NSs were maintained,as HMF-exposed NSs were positive for NSC markers(Nestin and Sox2),could differentiate into neurons and astrocyte/glial cells and be passaged continuously.In addition,adult mice exposed to the HMF for one month were observed to have a greater number of proliferative cells in the subventricular zone.These findings indicate that continuous HMF-exposure increases the proliferation of NPC/NSCs,in vitro and in vivo.HMF-disturbed NPC/NSCs production probably affects brain development and functions,which provides a novel clue for elucidating the cellular mechanism of the bio-HMF response.
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