【摘 要】
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Neuropathic pain following periphery injury or DRG injury is likely due to increased excitatory contacts between sympathetic nerves and dorsal root ganglia(DRG)neurons via sympathetic efferent nerve f
【机 构】
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Department of Physiology and Pathophysiology,School of Basic Medical Sciences,Xi'an Jiaotong Univer
【出 处】
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第九届海内外华人神经科学家研讨会(The 9th Symposium for Chinese Neuroscientis
论文部分内容阅读
Neuropathic pain following periphery injury or DRG injury is likely due to increased excitatory contacts between sympathetic nerves and dorsal root ganglia(DRG)neurons via sympathetic efferent nerve fiber sprouting into DRG.So inhibition of sympathetic nerve sprouting dramatically attenuates neuropathic pain,but the problem how to inhibit sympathetic nerve sprouting is yet unsolved.Now although the molecular mechanism of sympathetic nerve sprouting remains unclear,it was known that injured DRG neurons hyperexcitability activity was involved.Lacosamide(LCM),a novel antiepileptic,inhibited neurons excitability via selectively enhancing slow inactivation and was used as analgesic on painful diabetic neuropathy.So we proposed LCM may block sympathetic sprouting.We applied LCM and saline to chronic compression DRG(CCD)model rats for continually 5 days right after injury,respectively.Then we examined the withdrawal mechanical threshold of hind paw of rats; 15 days later after injury we observed the sympathetic nerves by immunohistochemical staining with anti-tyrosine hydroxylase antibodies in L4,L5 DRG slice,tested the L4,L5 DRG neurons excitability and persistent Na+current from both LCM treated rat group and vehicle rat group.Compared between the two groups,we found LCM injection significantly inhibited sympathetic sprouting,relieved the pain related behavior,reduced the injured DRG neurons excitability and persistent Na+current.Collectively,the study suggests early application of LCM may effectively alleviate neuropathic pain via inhibiting sympathetic nerve sprouting.
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