Use of Isomers to Isolate Transcriptional Modulation by Active Moieties of Chemicals and Drugs

来源 :2005 World DNA and Genome Day(2005中国(大连)国际DNA和基因组节大会) | 被引量 : 0次 | 上传用户：hq10000002

【摘要】

：

The genomic signature underlying a specific biological effect of a chemical or drug can be isolated by comparing the microarray-generated signatures of active and inactive isomers.Application of this

【作者】

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Peter S.Spencer Min-Sun Kim Mohammad I.Sabri Michael R.Lasarev Seyed B.Hashemi Xinfang Lu Dongseok Choi Srinivasa Nagalla Peter S.Spencer

【机构】

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Center for Research on Occupational and Environmental Toxicology, Oregon Health Science University 3

【出处】

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2005 World DNA and Genome Day(2005中国(大连)国际DNA和基因组节大会)

【发表日期】

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2005年12期

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　　The genomic signature underlying a specific biological effect of a chemical or drug can be isolated by comparing the microarray-generated signatures of active and inactive isomers.Application of this methodology to active (neurotoxic) and inactive (nonneurotoxic) diacetylbenzene isomers showed conservatively that less than half of the genes modulated by the former were specific to the active compound.This broadly applicable approach markedly increases the efficiency by which transcriptional profiles can be related to a chemical-or drug-induced phenotype.

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Use of Isomers to Isolate Transcriptional Modulation by Active Moieties of Chemicals and Drugs

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