【摘 要】
：
Porcine reproductive and respiratory syndrome (PRRS) has caused large economic losses in the swine industry in recent years.Cunrent PRRS vaccines not effectively prevent and control this disease.Conse
【机 构】
：
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology,Chinese Acad
【出 处】
：
2013国际猪繁殖与呼吸综合征学术研讨会
论文部分内容阅读
Porcine reproductive and respiratory syndrome (PRRS) has caused large economic losses in the swine industry in recent years.Cunrent PRRS vaccines not effectively prevent and control this disease.Consequently,there is a need to develop a new antiviral strategy.MicroRNAs play critical roles in intricate host-pathogen interaction networks,but the involvement of miRNAs during PRRS virus (PRRSV) infection is not well understood.In this study,pretreatment with miR-26a induced a significant inhibition of PRRSV replication and remission of the cytopathic effect in Marc-145 cells infected with either the PRRSV VR2332 strain or with the highly pathogenic PRRSV JXwn06 strain.
其他文献
Elucidating protein-protein interactions between viral and host cellular proteins is critical to understanding viral pathogenesis.A yeast two-hybrid screen revealed that both major PRRSV envelope prot
Main objective:Study the effect of a pre-viral infection with porcine reproductive and respiratory syndrome virus (PRRSV) on a bacterial infection by Actinobacillus pleuropneumoniae (App) in vitro.Spe
Introduction Like other arteriviruses,PRRSV 5 UTR is believed to carry a variety of cis-acting elements that regulate the discrete steps of viral life cycle.But the regulatory function and mechanism n
Main objective:The main goal of this research is to study the impact of PRRSV/PCV co infections in a new cellular model,the NPTr-CD 163 cells.Specific objectives:-Test NPTr-CD163 cells for permissivit
目的 将猪2型圆环病毒(PCV2) ORF2基因重组支气管败血波氏杆菌(Bb),获得能表达猪2型圆环病毒Cap蛋白的减毒支气管败血波氏杆菌,针对猪2型圆环病毒引起的猪多系统功能障碍性疾病,开发一种新型疫苗,利用Bb能在猪呼吸道黏膜上皮细胞有效和有限地定殖并激发黏膜免疫的能力,将PCV2的免疫原性蛋白通过呼吸道途径进行免疫,从而达到预防PCV2的感染,为该重组菌株作为候选疫苗提供科学依据.
GP5,the major glycoprotein of PRRSV,is considered as one possible target of neutralizing antibodies,which however appear only late in infection.This was attributed to the presence of a "decoy epitope"
Porcine reproductive and respiratory syndrome (PRRS) is a swine disease of significant economic importance that causes reproductive and respiratory problems in pigs.The replicase non-structural protei
Introduction N-linked glycosylation of the GP5 protein is involved in diverse functions such as virus infectivity,receptor binding and immune response.Potential N-glycosylation sites were observed at
Porcine reproductive and respiratory syndrome (PRRS) is an economically important disease in swine-producing areas.Many vaccine strategies have been developed to control the disease,but none have yet
The study was aimed at determining the effect of HP-PRRSV on HPS in co-infection.The infB gene,which is conserved among different HPS serotypes and different species,was amplified using PCR from extra