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  5. Discovery and characterization of the involvement of a cellular membrane fusion protein in PRRSV rep

Discovery and characterization of the involvement of a cellular membrane fusion protein in PRRSV rep

来源 :2013国际猪繁殖与呼吸综合征学术研讨会 | 被引量 : 0次 | 上传用户：fj123521
【摘 要】
：
Elucidating protein-protein interactions between viral and host cellular proteins is critical to understanding viral pathogenesis.A yeast two-hybrid screen revealed that both major PRRSV envelope prot
【作 者】
：
J.A.Hicks D.Yoo H.C.Liu 
【机 构】
：
Department of Animal Science, North Carolina State University, Raleigh, NC
【出 处】
：
2013国际猪繁殖与呼吸综合征学术研讨会
【发表日期】
：
2013年12期
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论文部分内容阅读
Elucidating protein-protein interactions between viral and host cellular proteins is critical to understanding viral pathogenesis.A yeast two-hybrid screen revealed that both major PRRSV envelope proteins GP5 and M interact with the cellular membrane fusion protein Snapin.Snapin is an accessory protein of the SNARE complex,the core intracellular membrane fusion mediator in eukaryotic cells.RNA interference (RNAi) technology was utilized to understand the potential involvement of the GP5/M interaction with Snapin in the PRRSV lifecycle.
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