【摘 要】
：
Pancreaticobiliary maljunction (PBM) or choledochal cyst is a high risk factor for biliary tract cancer especially in Asian people.In PBM, since the pancreatic duct and bile duct converge outside the
【机 构】
：
Third Department of Surgery Tokyo Medical University Japan
论文部分内容阅读
Pancreaticobiliary maljunction (PBM) or choledochal cyst is a high risk factor for biliary tract cancer especially in Asian people.In PBM, since the pancreatic duct and bile duct converge outside the duodenal wall beyond the influence of the sphincter of Oddi, pancreatic juice and bile are constantly mixed, producing a variety of harmful substances.Because of this, the biliary mucosa is repeatedly damaged and repaired, which causes an acceleration of cell proliferative activity and multiple gene mutations.
其他文献
Epigenetic abnormalities participate with genetic mutations to cause cancer; consequently epigenetic intervention of cancer has emerged as a promising avenue toward cancer therapy, with several synthe
HPVs are small, double-stranded DNA viruses that infect mucosal and cutaneous epithelial tissues.Since HPVs do not encode a viral DNA polymerase, these viruses are completely dependent on the host cel
Head and neck cancer (HNC) is the sixth most common cancer and is responsible for almost 200,000 deaths worldwide each year.Both local regional recurrences and lymph node metastasis (LNM) are associat
In cases of differentiated thyroid carcinoma, the presence or absence of invasion into the circumferential organs is an important prognostic factor.Surgical procedures include circular resection of th
The POU domain transcription factor Oct-4 (POU5F1 or Oct-3) is a member of the homeobox gene family and is specifically expressed in totipotent mouse and human embryonic stem (ES) and germ cells.It is
The invasive power of cancer cells is often related to their intrinsic mechanical properties.Atomic Force Microscopy (AFM) has proved itself to be the technique of choice to investigate living cells p
During tumor progression, tumor cells foster a tolerant microenvironment and the activation of many immunosuppressive mechanisms that act in concert to counteract effective immune responses.Therefore,
Many studies have produced inconsistent support for the hypothesized role of stressful life events in breast cancer risk.One major factor contributing to the inconsistent data could be that difference
CD4+ Th17 cells can activate CD8+ cytotoxic T lymphocytes (CTL) and induce antitumor immunity leading to eradication of established tumors.However, the mechanism of CTL activation by Th 17 cells and t
Oral squamous cell carcinoma (OSCC) and other head and neck squamous carcinoma constitute a microenvironment characterized by the infiltration of distinct inflammatory cells, predominantly T cells, in