In addition to the Rb, The Role of HPV E7 Associated Proteins in Tumor Progression

来源 :2011第四届世界癌症大会 | 被引量 : 0次 | 上传用户：SFAFFDAF

【摘要】

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【作者】

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Hung-Shu Chang

【机构】

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Department of Life Sciences, College of Bioscience and Biotechnology National Cheng Kung University

【出处】

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2011第四届世界癌症大会

【发表日期】

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2011年3期

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　　HPVs are small, double-stranded DNA viruses that infect mucosal and cutaneous epithelial tissues.Since HPVs do not encode a viral DNA polymerase, these viruses are completely dependent on the host cell machinery for DNA replication except an origin-binding protein and a replicative DNA helicase.The functions of two viral proteins, E6 and E7, from high risk type HPVs, are reflected in many of the cellular proteins with which they interact.Among a variety of cellular targets, the effects of E6 and E7 on p53 and pRb as well as on many other cellular proteins have been extensively investigated in the past.

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In addition to the Rb, The Role of HPV E7 Associated Proteins in Tumor Progression

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