Single-molecule multi-color FRET reveals the fork regression mechanism of Werner syndrome helicase

来源 :8th IUPAP International Conference on Biological Physics(第八届 | 被引量 : 0次 | 上传用户：donnastinsbt

【摘要】

：

DNA is constantly damaged.Various DNA lesions stall DNA replication, making the reactivation of stalled replication forks a major challenge for DNA replication.

【作者】

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Sungchul Hohng

【机构】

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DepartmentofPhysics&Astronomy,DepartmentofBiophysics&ChemicalBiology,SeoulNationalUniversity,Seoul15

【出处】

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8th IUPAP International Conference on Biological Physics(第八届

【发表日期】

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2014年6期

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DNA is constantly damaged.Various DNA lesions stall DNA replication, making the reactivation of stalled replication forks a major challenge for DNA replication.In diverse reactivation pathways of stalled replication, the replication fork as a three-way junction is converted into a Holliday junction via the process called replication fork regression.However,the coordination mechanism of these DNA structural transitions by molecular motors remains unclear.

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Single-molecule multi-color FRET reveals the fork regression mechanism of Werner syndrome helicase

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