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The presence of impurities in commercial products can seriously affect their quality, resulting in more stringent requirements for impurities management.HPLC is an effective method to determine impurities in pharmaceutical products.When an impurity that is present at trace levels becomes the target of quantitation, it may not be detectable due to insufficient sensitivity with the existing analytical conditions.This makes it necessary to determine the analytical conditions that will provide the required higher sensitivity.One approach to this is to implement sample pretreatment that includes the extraction and concentration of the analyte.