pH-sensitive polysaccharide derivatives-modified liposomes as antigen delivery vehicles for cancer i

来源 :The Third Symposium on Innovative Polymers for Controlled De | 被引量 : 0次 | 上传用户：myywy123456

【摘要】

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【作者】

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Eiji Yuba Shinya Uesugi Ayaka Yamaguchi Atsushi Harada Kenji Kono

【机构】

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Department of Applied Chemistry,Graduate School of Engineering,Osaka Prefecture University,1-1 Gakue

【出处】

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The Third Symposium on Innovative Polymers for Controlled De

【发表日期】

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2014年6期

【关键词】

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pH-sensitive liposome polysaccharide dendritic cell cancer immunotherapy

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　　For establishment of cancer immunotherapy,efficient antigen carriers are needed to deliver antigen into the cytosol of dendritic cells (DCs) and induce antigen-specific cellular immune responses.pH-Sensitive liposomes are useful as an intracellular delivery system for their ability to transfer their contents into the cytosol by iH-resionsive fusion with endosomal membrane.We previously reported cytoplasmic delivery using liposomes modified with carboxylated poly(glycidol)s [1].

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pH-sensitive polysaccharide derivatives-modified liposomes as antigen delivery vehicles for cancer i

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