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  5. Smart hydrogel beads with potential therapeutic target in Caco-2 colon cancer cells

Smart hydrogel beads with potential therapeutic target in Caco-2 colon cancer cells

来源 :The Third Symposium on Innovative Polymers for Controlled De | 被引量 : 0次 | 上传用户：tangyujia
【摘 要】
：
N,N,N-trimethyl chitosan (TMC),a partially quatemized derivative of chitosan (CT) presents good properties in relation to CT [1].The presence of methyl groups increases the mucoadhesion of TMC with mu
【作 者】
：
Alessandro F.Martins Johny p.Monteiro Suelen P.Facchi Letícia C.Bonkovoski Cleiser T.P.Silva Adriana P.Gerola Samara R.Nocchi Celso V.Nakamura Emerson M.Girotto Adley F. Rubira Edvani C.Muniz 
【机 构】
：
Universidade Estadual de Maringá-Dep.de Química-Av.Colombo,5790-87020-900-Maringá,Brasil;Universidad
【出 处】
：
The Third Symposium on Innovative Polymers for Controlled De
【发表日期】
：
2014年6期
【关键词】
：
N N N-trimethyl chitosan alginate beads hydrogels 
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论文部分内容阅读
　　N,N,N-trimethyl chitosan (TMC),a partially quatemized derivative of chitosan (CT) presents good properties in relation to CT [1].The presence of methyl groups increases the mucoadhesion of TMC with mucosal membranes and increases the absorption efficacy of drugs,especially in regions such as the large and small intestine [1].Thus,the aim of this work was to prepare new hydrogel beads based on TMC/alginate complexes (TMC/ALG) containing silver and gold nanoparticles (NPs) with potential tumor-targeted combination therapy.The NPs are commonly employed for the diagnostic and therapeutic agents for cancer cells [2].
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