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  5. Spatiotemporal delivery of small molecule therapeutics using a thermosensitive liposome loaded hydro

Spatiotemporal delivery of small molecule therapeutics using a thermosensitive liposome loaded hydro

来源 :The Third Symposium on Innovative Polymers for Controlled De | 被引量 : 0次 | 上传用户：iamfly2000
【摘 要】
：
Lysolipid thermosensitive liposomes (LTSLs) can be utilised to release their drug payload through the local application of a hyperthermic pulse [1].This study looked at the application of drug-loaded
【作 者】
：
H.O'Neill C.Herron C.Hastings A.Lopez-Noriega H.M.Kelly F.J.O'Brien E.Ruiz-Hernandez G.P.Duffy 
【机 构】
：
Tissue Engineering Research Group,Department of Anatomy,Royal College of Surgeons in Ireland,Dublin,
【出 处】
：
The Third Symposium on Innovative Polymers for Controlled De
【发表日期】
：
2014年6期
【关键词】
：
thermosensitive liposome hydrogel drug delivery system stimuli-responsive trigge 
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　　Lysolipid thermosensitive liposomes (LTSLs) can be utilised to release their drug payload through the local application of a hyperthermic pulse [1].This study looked at the application of drug-loaded LTSLs encapsulated within a thermoresponsive chitosan/β-glycerophosphate (β-GP) gel for controlled release of DFO.Duration of hyperthermic pulse,delayed application of hyperthermic pulse and a combination of encapsulated and free loaded DFO within this system to induce a multiple burst release profile was assessed.
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