【摘 要】
：
Cardiovascular diseases (CVDs), represented by disorders of heart and blood vessels, are a major health problem across the world, as they account for up to 30% of all deaths worldwide.Most of CVDs are
【机 构】
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Department of Pharmacy University of Pisa Italy
【出 处】
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2013百奥泰波兰重大疾病临床峰会
论文部分内容阅读
Cardiovascular diseases (CVDs), represented by disorders of heart and blood vessels, are a major health problem across the world, as they account for up to 30% of all deaths worldwide.Most of CVDs are caused by atherosclerosis, a process of vessel wall degradation and calcification, leading to narrowing up to occlusion of the blood vessel.1 To date, patients affected by atherosclerosis are faced with different treatment opportunities, represented by medical therapy, coronary artery bypass graft surgery (CABG) and percutaneous coronary intervention (PCI).This latter, in particular, is currently the most frequently exploited treatment.Different techniques and devices have been developed to either remodel or remove causes of acute and chronic vessel obstruction, increasing luminal cross-sectional area and improving blood flow.However, despite improvement in equipments, limitations still exists.Actually, patients may experience abrupt vessel closure at the treated site, localized thrombus and vessel dissection.Moreover, recurrence of restenosis, within 3 to 12 months after the treatment, may affect up to 60% of patients.Drug-eluting stents (DES) revolutioned the field of interventional cardiology, allowing to reduce the rate of restenosis and the need for repeated vascularization.However, some concerns still remain about their safety, particularly due to the rare but potentially life-threatening complication of in-stent thrombosis.2 Accordingly, vascular intervention needs to be improved, thus resulting in an interesting field of research.
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