【摘 要】
：
In the past decade, we have learned that tolerance in organ transplantation is linked to the development and pets istence of regulatory T cells (Treg).Therapeutic administration of Tregs has proven ef
【机 构】
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University of California USA
论文部分内容阅读
In the past decade, we have learned that tolerance in organ transplantation is linked to the development and pets istence of regulatory T cells (Treg).Therapeutic administration of Tregs has proven efficacy to control allograft rejection through bystander suppression and infectious tolerance in multiple mouse and humanized mouse models.Alloantigen-specific Tregs are more effective and potentially safer than non-specific Tregs by offering targeted therapy instead of indiscriminate regulation.Specifically, donor alloantigen-reactive Treg therapy has the potential to induce tolerance to the transplanted organ without impeding protective immune responses.
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