【摘 要】
：
变应性鼻炎(AR)的发病机制及其症状受到基因及环境两方面因素的影响,尽管特异性免疫治疗(SIT)对白种人AR的远期疗效的研究已有一些报道,然而对中国人种的疗效目前还是空白.本研究探讨了SIT对屋尘螨导致的国人的变应性鼻炎的远期疗效以及预防作用.方法 研究对象为158名伴有或不伴有哮喘的对屋尘螨过敏的AR患者,3年治疗共脱落12名,其中SIT组8名,不满一年脱落3名,不满二年脱落3名,不满三年脱落2
【机 构】
：
中山大学附属第一医院耳鼻咽喉科 新加坡国立大学医学院耳鼻咽喉科
【出 处】
：
中华医学会2014年全国变态反应学术会议
论文部分内容阅读
变应性鼻炎(AR)的发病机制及其症状受到基因及环境两方面因素的影响,尽管特异性免疫治疗(SIT)对白种人AR的远期疗效的研究已有一些报道,然而对中国人种的疗效目前还是空白.本研究探讨了SIT对屋尘螨导致的国人的变应性鼻炎的远期疗效以及预防作用.方法 研究对象为158名伴有或不伴有哮喘的对屋尘螨过敏的AR患者,3年治疗共脱落12名,其中SIT组8名,不满一年脱落3名,不满二年脱落3名,不满三年脱落2名;对照组4名,不满一年脱落1名,不满二年脱落1名,不满三年脱落2名;146名患者完成3年治疗,其中106名患者完成了为期3年的标准化螨变应原的皮下注射(SIT组,n=106)以及药物治疗,40名患者完成了3年药物治疗(对照组,n=40)仅接受药物治疗.对比观察两组患者在基线期、三年SIT治疗结束时、以及停止SIT治疗两年时三个时间点的各项临床指标:症状治疗积分(SMS)、视觉模拟量表评分(VAS)、总IgE (tlgE)、特异性IgE (slgE)的变化,同时对两组AR患者新发生哮喘的情况进行分析.
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目的 研究青藤碱对变应性鼻炎的治疗作用并初步探究其相关机制.方法 采用4-6周BALB/c雄性小鼠进行实验研究.将小鼠分为三组,正常组,变应性鼻炎组及青藤碱组,每组十只.其中变应性鼻炎组和青藤碱组每只小鼠在第0,7,14天腹腔注射含25μg卵清蛋白和1mg氢氧化铝的PBS溶液1ml,正常组注射普通PBS溶液1ml.第21天开始,变应性鼻炎组和青藤碱组小鼠每天用含500μg卵清蛋白的PBS溶液滴鼻1