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  5. Patterns of nucleosome occupancy around transcription factor binding sites in human cells

Patterns of nucleosome occupancy around transcription factor binding sites in human cells

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户：zhaimeng2
【摘 要】
：
Background: Transcription factor (TF) binding at specific DNA sequences is the fundamental step in transcriptional regulation, and is highly dependent on the local chromatin structure context in eukar
【作 者】
：
聂玉敏 孙啸 
【机 构】
：
生物电子学国家重点实验室,生物科学与医学工程学院,东南大学,南京,210096
【出 处】
：
第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
【发表日期】
：
2014年4期
【关键词】
：
nucleosome transcription factor binding site clustering 
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　　Background: Transcription factor (TF) binding at specific DNA sequences is the fundamental step in transcriptional regulation, and is highly dependent on the local chromatin structure context in eukaryotes.The basic unit of chromatin structure is the nucleosome.There are specific patterns of nueleosome occupancy around transcription factor binding sites (TFBSs).However, previous studies have focused mainly on nucleosome occupancy around TFBSs of a few specific TFs.We therefore need to collect more TFBSs to systematically investigate the common features of nucleosome occupancy around TFBSs.
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