泛素特异性加工酶USP28 的生物学意义及原核表达

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：hjh8607

【摘要】

：

泛素特异性加工酶USP28(ubiquitin specific peptidase 28,USP28)在调控DNA 损伤,转录因子的表达以及多种癌细胞中发挥着重要的作用。转录因子c-myc 依赖泛素降解,其E3 泛素化酶是SCFFbw7α,而USP28 通过识别SCFFbw7α 抑制c-myc 的降解,促进细胞增殖；此外,USP28 是DNA 损伤检查点的关键调控因子,DNA 损伤可以导致USP

【作者】

：

刘珍珍郑一超程婷邹蓓蕾张淑霞张佳琪刘宏民

【机构】

：

郑州大学药学院,郑州大学新药研究开发中心,河南郑州 450001

【出处】

：

2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

USP28 肿瘤去泛素化生物学意义

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泛素特异性加工酶USP28 的生物学意义及原核表达

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