Design and synthesis of novel triazole-pyrimidine hybrids as potent LSD1 inhibitors

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：liongliong542

【摘要】

：

Lysine specific demethylase 1(LSD1)plays an important role in the epigenetic control of gene expression and it has been found overexpressed in various tumor tissues.

【作者】

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Zhonghua Li Kai Zhu Li-Ying Ma Lixing Song Hao Li Biao Hu Haoming Wei Ying Liu Hong-Min Liu

【机构】

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New Drug Research & Development Center,School of Pharmaceutical Sciences,Zhengzhou University,100 Ke

【出处】

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2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

LSD1 triazole pyrimidine

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　　Lysine specific demethylase 1(LSD1)plays an important role in the epigenetic control of gene expression and it has been found overexpressed in various tumor tissues.

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Design and synthesis of novel triazole-pyrimidine hybrids as potent LSD1 inhibitors

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