Design,Synthesis,and Biological Evaluation of Triazol o-pyrimidine Derivatives as Antiviral Drug

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：ankang1989

【摘要】

：

Viruses are a kind of individual small,simple structures,containing only a single nucleic acids(DNA or RNA),which are parasitic in living cells to copy and proliferate.

【作者】

：

Ying-Chao Liu Dong-Jun Fu Feng Li Qing-Hui Liu Hui-Min Xing Xiao-Cui Yang Hong-Min Liu

【机构】

：

School of Pharmaceutical Sciences and New Drug Research & Development Centre,ZhengZhou University,Zh

【出处】

：

2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Viruses are a kind of individual small,simple structures,containing only a single nucleic acids(DNA or RNA),which are parasitic in living cells to copy and proliferate.

其他文献

Prokaryotic expression and purification of human MTH1 and its inhibitor screening

会议

Design and synthesis of novel LSD1 inhibitors based on pyrimidine-thiourea hybrids

As the first identified histone demethylase,Lysine specific demethylase 1(LSD1)plays an important role in epigenetic regulation of gene activation and repression.

会议

epigeneticsLSD1pyrimidine-thiourea hybrids

Domino Synthesis of Novel Indolyl Tetrahydropyrano[4,3-c]pyrazole Derivatives as Anticancer Agents

School of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001,China Five and six membered aza-heterocyclic systems are scaffolds of many efficacious drugs.

会议

Domino synthesisindolyl 1467-tetrahydropyrano[43-c]pyrazole derivativesant

新型5,6-二氢-6-烷基-2-吡喃酮衍生物的设计、合成及肿瘤细胞增殖抑制活性研究

5,6-二氢-6-烷基-2-吡喃酮代表了一大类的生物活性有机分子。比如：Pironetin［1-3］,(-)Butungolide,CytostatinRasfonin,Callystatin A,Fostriecin,以及Phoslactormycin B 等均表现出了良好的抗肿瘤活性。

会议

56-二氢-6-烷基-α-吡喃酮肿瘤细胞增殖抑制活性

Prokaryotic expression of human histone lysine specific demethylase 2 and its biological significanc

LSD1(also known as KDM1A)is the first identified histone lysine demethylase.It converts mono-or di-methylated histone H3(H3K4me1/me2)to unmodified H3[1].

会议

LSD2protein expressioninhibitor

The mechanism of Histone lysine-specific demethylase 1 regulating TGF-β1 expression in gastric epith

Lysine specific demethylase 1(LSD1),the first identified histone lysine demethylase by Yang Shi group in 2004[1],specifically catalyzes demethylation of mono-and di-methylated lysine 4 and lysine 9 of

会议

LSD1TGF-β1ChIPGES-1

An in vitro model of MDM2-p53 interaction

The p53 tumor suppressor protein plays a key role in regulation of several important cellular processes,including cell cycle,apoptosis,DNA repair and angiogenesis.

会议

MDM2p53InhibitorFRET

Biological Evaluation of Brominated Chalcone Derivative

Chalcone,which exist in the Kava plant[1] aroused considerable interest recently for their various bioactivities,including anti-inflammatory,anti-microbial and especially anti-cancer activities[2].

会议

Chalcone derivativesynthesizedanti-tumor

Research on Synthesis of Efavirenz

Efavirenz,trade name Stocrin,is one of the non-nucleoside HIV-1 reverse transcriptase inhibitor which is widely used in clinic in the world.

会议

EfavirenzAsymmetric Synthesiscrystal saltChemical resolution

Gradient Cooling Crystallization for Synthesis of Efonidipine

Efonidipine is a higher and longer effective Ca2+channel blocker with L-type and T-type Ca2+channel blocking activity and is a unique antihypertensive clinical drug with renal protection.

会议

Efonidipinesynthesisgradient crystallization

Design,Synthesis,and Biological Evaluation of Triazol o-pyrimidine Derivatives as Antiviral Drug

其他学术论文