High Expression of NBR1 Proteins May Be Associated with Epithelial-mesenchymal Transition (EMT) in K

• 作 者: LiuBing;ManQiwen;ChenGang;ZhaoYifang;
• 机 构: Department of Oral and Maxillofacial Surgery,School and hospital of Stomatology,Wuhan University,Chi
• 出 处: 2014xi`an Conference of International Society for Maxillofac
• 发表日期: 2014年期

　　Purpose: The aim of this study was to evaluate the expression of NBR1 in keratocystic odontogenic tumours(KCOT),and also to investigate its possible relationship with epithelial-mesenchymal transition(EMT)which has an important indication of invasion.Methods: We detected the expression levels of NBR1 and some key EMT-related proteins(Snail,Slug,Twist,E-cadherin,and N-cadherin)in clinical samples of KCOT and radicular cysts by immunohistochemistry and then detected their mRNA expression by real-time quantitative polymerase chain reaction(qPCR).The correlation between NBR1 and the tested EMT-related proteins in KCOT was explored using Spearmans rank correlation,followed by cluster analysis.