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Bachground and Objective s Hemophagocytic lymphohistiocytosis (HLH) patients presented a specific cytokine pattern consisting of significantly elevated interferon-gamma (IFN-γ) and interleukin (IL)-10 with mildly elevated IL-6.EBV was shown to be the most frequently detected pathogen in this disease and putatively to be the major cause of the acquired or secondary HLH (sHLH) or non-familial HLH (nFHL).