Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma

来源 :The 35th World Congress of the International Society of Hema | 被引量 : 0次 | 上传用户：db0928

【摘要】

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【作者】

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Lu Jiang Zhao-Hui Gu Zi-Xun Yan Xia Zhao Wei-Li Zhao Zhu Chen Sai-Juan Chen

【机构】

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State Key Laboratory of Medical Genomics,Shanghai Institute of Hematology,Rui Jin Hospital affiliate

【出处】

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The 35th World Congress of the International Society of Hema

【发表日期】

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2014年5期

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Background Natural-killer/T-cell lymphoma (NKTCL) is a malignant proliferation of CD56+/cytoCD3+ lymphocytes and constitutes a heterogeneous group of aggressive lymphoma prevalent in Asian and South American populations.NKTCL represents a distinct clinicopathologic entity of non-Hodgkins lymphoma,characterized by male predominance,strong association with Epstein-Barr virus (EBV) infection,prominent tissue necrosis and aggressive clinical course.

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Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma

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