【摘 要】
：
Introduction: Obesity in men is frequently associated with testosterone deficiency.Adipose tissue is an active endocrine organ producing substances (e.g., estrogens, cortisol, leptin, inflammatory cyt
【机 构】
：
Bayer Pharma, Germany Gulf Medical University School of Medicine, UAE
【出 处】
：
MIT`s 1st Annual World Congress of Diabetes-2012(2012第一届糖尿病大
论文部分内容阅读
Introduction: Obesity in men is frequently associated with testosterone deficiency.Adipose tissue is an active endocrine organ producing substances (e.g., estrogens, cortisol, leptin, inflammatory cytokines) that suppress endogenous testosterone production.This study analysed effects of normalization of testosterone in hypogonadal men.Methods: Open-label, single-center, cumulative, prospective registry study of 255 men (mean age 60.6 8.0 years), with testosterone levels≤3.5 ng/mL receiving parenteral testosterone undecanoate 1000 mg/12 weeks after an initial 6-week interval.Results: After 5 years the following changes occurred: testosterone increased from 2.87 ± 0.4 to 5.26 ± 0.44 ng/mL.Body weight (kg) decreased from 106.22 ± 16.93 (minimum: 70, maximum: 139) to 90.07 ± 9.51 (min 74.00, max 115).The statistical significance was p<0.0001 vs baseline and vs the previous year over 5 years indicating a continuous weight.Waist circumference (cm) declined from 107.24 ± 9.14 (min 86, max 129) to 98.46 ± 7.39 (min 84, max 117) (p<0.0001 vs baseline and vs the previous year over 5 years).Body mass index (BMI, m/kg2) declined from 33.93 ± 5.54 (min 21.91, max 46.51) to 29.17 ± 3.09 (min 22.7;max 36.7l) (p<0.0001 vs baseline and vs the previous year over 5 years).The mean per cent weight loss after 1 year was 4.12 ± 3.48%, after 2 years 7.47 ± 5.01%, after 3 years 9.01 ± 6.5%, after 4 years 11.26 ± 6.76% and after 5 years 13.21 ± 7.24%.At baseline, 96% of men had a waist circumference of ≥94 cm.This proportion decreased to 71% after 5 years.Conclusions: Normalising testosterone resulted in progressive loss of weight, waist circumference and BMI over the full 5 years of the study.
其他文献
To examine if diabetes affects the seniors mortality from pneumonia, the US NHANES Ⅲ follow-up study data was used.After cleaning those who were other minorities, had been hospitalized for pneumonia i
The incidence of depression is higher in adolescents and young adults with diabetes compared to their peers without diabetes.Depression has a negative effect on physical, emotional and social wellbein
The purpose of this study is to determine the prevalence of fall and its associated factors among elderly diabetes type 2 patients attending a tertiary center in Malaysia.We conducted a cross sectiona
Glycemic control is fundamental in the management of diabetes but is also essential for patients suffering from stress hyperglycemia as seen in surgical patients, critically ill patients, wasting canc
We found possibilities for fermented bilberries, European wild-growing low-bush blueberries (Vaccinium myrtillus), in the formulation of foods with metabolic merits.Fermented bilberries were seen to r
Objective: to elucidate risk factors for macrovascular disease in elderly people with diabetes mellitus.Methods: A randomized, controlled, multi-centre, prospective intervention trial was performed.A
Recent evidences suggested intensive control of oxidative stress to be more effective way in the management in diabetes mellitus (DM) due to an excessive generation of free radicals in patients who su
As the 21st century advances, evidence-based medicine (EBM) has come to be regarded as essential in all field of medical sciences and practical medicine.Creating medicines have been searching for base
Adipose inflammation and insulin resistance play causal roles for type 2 diabetes.HFCS is the most-used sweetener in the United States, substantially replacing sucrose.In this study, we compared the m
1.The limitation of present medication for T2DM Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disorder disease, which results from defects in both insulin secretion and insulin action.