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Objective Imatinib combined with chemotherapy for induction and intensification therapy has be come the standard strategy for Philadelphia-positive acute lymphocytic leukemia (Ph+ALL).Anyhow,intensified chemotherapy lead to about 5 %of early death.Because we believed that imatinib plays the most important role in Ph+ALL treatment,we started Ph+ALL-HX-200803 trial to test the effect of combining imatinib and low dose chemotherapy.