MESENCHYMAL STEM CELLS INHIBIT TUMOR GROWTH BY EXPANDING INNATE-LIKE MHC CLASS Ib-RESTRICTED CD8+T C

来源 :The 1st NI-CMI Joint Conference(第一届CMI-NI免疫学国际研讨会) | 被引量 : 0次 | 上传用户：yinxiaoyi5858

【摘要】

：

The role of nonclassical MHC class Ib-restricted CD8+ T cells in tumor immunity is largely elusive in mammalians.Mesenchymal stem cells (MSCs) are known to affect tumor growth and present antigens to

【作者】

：

Peishun Shou Qing Chen Weifang Ling Ying Wang Yufang Shi

【机构】

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Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biologica

【出处】

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The 1st NI-CMI Joint Conference(第一届CMI-NI免疫学国际研讨会)

【发表日期】

：

2015年11期

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The role of nonclassical MHC class Ib-restricted CD8+ T cells in tumor immunity is largely elusive in mammalians.Mesenchymal stem cells (MSCs) are known to affect tumor growth and present antigens to T cells.Here we show that administration of C57BL/6 MSCs inhibited B16-F0 tumor growth in KbDb-/-mice (B6 background, MHC class Ia knockout) while not in wild-type C57BL/6 mice.Anti-tumor effect of MSCs could also be observed inKbDb-/-CIITA-/-mice but not in β2m-/-mice (whole MHC class I knockout) or CIITA-/-mice (MHC class Ⅱ knockout).Interestingly, CD8+ T cells were significantly increased in tumor as well as in the peripheral after MSC injection in KbDb-/-mice.

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MESENCHYMAL STEM CELLS INHIBIT TUMOR GROWTH BY EXPANDING INNATE-LIKE MHC CLASS Ib-RESTRICTED CD8+T C

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