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The pathogenesis of inflammatory bowel disease (IBD), a common digestive disease, is very complicated and is involved with factors including genetic defect, disorders of the host immune function,and imbalance of gut microbiota.Dedicator of cytokinesis 2 (Dock2) is a guanine nucleotide exchange factor.Although it is known that Dock2 plays an important role in the migration and activation of different immune cells and Dock2 mutation has been identified in patients with digestive diseases, the in vivo role of Dock2 in colitis and bacterial infection has not been reported.In this study, we show that Dock2-/-mice are highly susceptible to Citrobacter rodentium infection-induced colitis.