【摘 要】
：
Ovarian cancer is the fifth most common cause of death from cancer in women.The standard first-line treatment is a combination of paclitaxel and carboplatin (DDP) or carboplatin alone.In the case of p
【机 构】
：
University of Modena and Reggio Emilia Italy
【出 处】
：
BIT Life Sciences 1st Annual World Cancer Congess-2008(2008中
论文部分内容阅读
Ovarian cancer is the fifth most common cause of death from cancer in women.The standard first-line treatment is a combination of paclitaxel and carboplatin (DDP) or carboplatin alone.In the case of progressive disease or drug resistance treatment with platinum, either alone or in combination, especially investigational compounds should be used.The mechanisms behind acquired resistance to cDDP and its derivatives are not clear yet, although it is evident that the process is multifactorial including, enhanced DNA repair.Within this context the folate pathway represent a well assessed target and drugs directed to this pathway often shows cross resistance towards platinum resistant ovarian carcinoma.New strategies should be adopted to overcome this problem.
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