【摘 要】
：
Tyrosine and tryptophan are precursors to dopamine and serotonin and are involved in partial regulation ofdopamine and serotonin synthesis.Changes in tyrosi
【机 构】
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Beijing army general hospital China
【出 处】
：
BITs 2rd Annual World Cancer Congress of Cardiology-2010(201
论文部分内容阅读
Tyrosine and tryptophan are precursors to dopamine and serotonin and are involved in partial regulation ofdopamine and serotonin synthesis.Changes in tyrosine and or tryptophan availability may influence dopamine-serotonin function that may cause widespread changes both in neurotransmission and psychopathology in patients with schizophrenia,bipolar-Ⅰ and related CNS disorders.Competitive transport with other amino acids or aberrant transport of these precursors across the cell membranes/blood brain barrier (BBB) can cause a limited availability of tyrosine and/or tryptophan to the brain.Transport of neutral amino acids including tyrosine, tryptophan and alanine, mainly occurs through L and A system.Aberrant tyrosine transport in schizophrenia, bipolar-Ⅰ disorders and autism, results from different investigations, functionality and the relationship between tyrosine, tryptophan and alanine transport in fibroblasts will be presented and discussed.
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