【摘 要】
：
The beta-3 adrenoreceptor (B3AR) is recognized as novel modulator of heart function.B3AR-/-mice show impaired cardiac functional compensation after pressure
【机 构】
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Division of Cardiology Johns Hopkins University USA
【出 处】
：
BITs 2rd Annual World Cancer Congress of Cardiology-2010(201
论文部分内容阅读
The beta-3 adrenoreceptor (B3AR) is recognized as novel modulator of heart function.B3AR-/-mice show impaired cardiac functional compensation after pressure overload.We therefore hypothesized that the selective B3AR agonist,BRL37344 (BRL), would protect the heart from pressure overload induced cardiac remodeling.Wild-type mice underwent transverse aortic constriction (TAC) for 3 weeks, resulting in increased LV mass, wall thickness, diastolic and systolic dimension, and reduced fractional shortening.
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