【摘 要】
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Background:To evaluate whether intra-arterial versus intravenous administration was more effective.Methods:Renal ischemia was induced by clamping the right renal vessels for 60 minutes after removal o
【机 构】
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Department of Urology,Fuzhou General Hospital
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Background:To evaluate whether intra-arterial versus intravenous administration was more effective.Methods:Renal ischemia was induced by clamping the right renal vessels for 60 minutes after removal of the left kidney.MSCs (1× 106) were administered through either the tail vein (TV) or the renal arter (RA),followed by reperfusion.We evaluated kidney function as well as tissue activities of malondialdehyde (MDA),superoxide dismutase (SOD),and glutathione peroxidase (GSH-Px).Histopathologic and immunohistochemical examina-tions were performed.To tracking MSCs in vivo,they were transfected with uc-mrfp).MSC retention and survival were assessed using bioluminescence imaging.We observed the effects of MSCs (1 × 106,2 × 106,and 5 × 106) on IR injury.
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