【摘 要】
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Intestinal ischemia reperfusion (I/R) injury is a pathophysiology involving both local tissue injury and remote organ dysfunction.Accumulating evidence confirmed that the infiltration of neutrophils i
【机 构】
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Department of General Surgery,Affiliated Drum Tower Hospital of Nanjing University Medical School,Na
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Intestinal ischemia reperfusion (I/R) injury is a pathophysiology involving both local tissue injury and remote organ dysfunction.Accumulating evidence confirmed that the infiltration of neutrophils is of central importance in mediating intestinal I/R injury,on the other hand,adequate neutrophils in the intestine could also benefit for the antibacterial transloacation and intestinal tissue repair.Consequ.ently,regulation of neutrophil immunity after intestinal I/R might be one of the most promising therapies for the control of intestinal injury.Wip1 is a serine/threonine protein phosphatase which acts as the master regulator of tumorigenesis.However,emerging evidence highlights the importance of Wip1 in regulating neutrophil development,maturation,and also in influencing neutrophil migration and pro-inflammatory cytokines production.Current opinions of Wip1 in regulating neutrophil immune responses offer the therapeutic potential for the treatment of intestinal injury in a Wip1-dependent manner.Taken together,we present our opinions here that Wip1 might be a new therapeutic target for treating intestinal I/R injury.
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