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Previously, we have proved the influence of emu oil on anti-inflammatory potential of curcumin.Aim of the present study was to formulate a nanoemulsion of curcumin for topical delivery to increase its photostability, and enhance its anti-inflammatory activity by using emu oil, having itself anti-inflammatory activity as a carrier and.permeation enhancer.Curcumin loaded nanoemulsion was prepared by employing emu oil as the oil phase and Cremophor RH 40 and Labrafil M 2125 CS as surfactant and co-surfactantrespectively.