• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. L-type Ca2+ channel mediates orexin-A-induced AMPK activation in hypothalamic ARC neurons

L-type Ca2+ channel mediates orexin-A-induced AMPK activation in hypothalamic ARC neurons

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：aglusaiy
【摘 要】
：
Aim: Orexin-A, a neuropeptide secreted by the neurons in lateral hypothalamic area (LHA), is one of the key factors for the regulation of feeding behavior.Here, we investigated the involvement of calc
【作 者】
：
Jun ZHOU Peng-fei WU Zhuang LI Fang WANG Jian-guo CHEN 
【机 构】
：
Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology,Wu
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
orexin-A L-type calcium channel AMPK neurpeptide Y food intake 
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Aim: Orexin-A, a neuropeptide secreted by the neurons in lateral hypothalamic area (LHA), is one of the key factors for the regulation of feeding behavior.Here, we investigated the involvement of calcium-dependent hypothalamic AMPK activation in the feeding behaviour regulation by orexin-A.Methods: We evaluated feeding behavior by using icv cannulation.
其他文献
Novel PPARγ binding activity modulator discovery based on the PPARγ-Gal4 chimera receptor and its mu
Aim: To discover novel PPARy modulator, PPARy-Gal4 chimera receptor and its mutant derivatives were applied to evaluate the binding activity of ligands and their molecular basis of interaction.Methods
会议
PPARγ modulatorchimera receptorbinding activity
Explore the molecular-descriptor-drug-action relationship inside ligand cellular system of nuclear r
Aim: Molecular descriptor is context-dependent, that is, the various interpretations of a specific molecular descriptor depend on the varying biological contexts.For example, molecular dipole can stan
会议
molecular-descriptor-drug-action relationshipligand cellular systemnuclear rec
Zebrafish-based traditional Chinese medicine(TCM) drug discovery and assessment platform
Zebrafish as a vertebrate animal model is increasingly used for in vivo drug discovery and for assessing compound toxicity and safety, for its several compelling experimental advantages including tran
会议
Evaluation of human monoclonal antibody toxicity, toxicokinetics and immunogenicity in cynomolgus mo
Aim: A human monoclonal antibody was administered intravenously for 4-week in cynomolgus monkeys.The aim of this study was to characterize the toxicity of the antibody and in particular, the exposure-
会议
toxicokineticsimmunogenicitycynomolgusmonoclonal antibodyADA
Cardiovascular protection effect of a novel Rho-kinase inhibitor, DL0805-2, and the potential drugga
Aim: Rho/Rho-kinase is an important new target for the treatment of cardiovascular diseases.The aim of this study was to investigate the cardiovascular protection effect of DL0805-2, a novel Rho-kinas
会议
ROCK1inhibitorVSMCHUVECisolated vesseldruggability
Upregulation of MRTF-A pathway is involved in 17β-estradiol-stimulated migration of MCF-7 breast can
Aim: Contrast to its proliferation activity on breast cancer, the effects of estrogen on breast tumor cell motility or invasion are more poorly understood.Here, the roles of MRTF-A pathway, the key do
会议
17β-estradiolmigrationbreast cancer cellsMRTF-ASMYD3
Tetrahydroxystilbene glucoside protects LPS-induced dopaminergic neurodegeneration via the inhibitio
Aim: Parkinson disease (PD) is one of the most common neurodegenerative diseases characterized by progressive dopaminergic (DA) neuronal loss in the substantia nigra (SN).Tetrahydroxystilbene glucosid
会议
Parkinson diseaseneuroinflammationmicroglial activationtetrahydroxystilbene g
Changes in genes expression and aberrant promoter methylation during polypeptide from Chlamys farrer
Aim: To establish a model that human HaCaT keratinocytes is transformed by multiple doses of UVB and investigate the mechanism of polypeptide from chlamys farreri (PCF) can inhibite the transformation
会议
PCF (polypeptide from chlamys farreri)UVBtransformationhuman HaCaT keratinocy
Effects of novel triazole-dithiocarbamate based LSD1 selective inhibitors on gastric cancer cell gro
The post-translational modifications of histone, eg methylation and demythalation,regulate chromatin structure as well as gene activation and repression.Lysinespecific demythelase 1 (LSD1), the first
会议
LSD1inhibitorepigeneticsgastric cancer
Relationship between methylation of RASSF1A and p16 genes and lung cancer
Aim: To explore the transcriptional expression and the promoter methylation of Ras association domain family 1A gene (RASSF1A) and p16 gene, and the major mechanisms for silencing of these two genes i
会议
RASSF1Ap16methylationlung cancer