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Aim: According to the changes that secondary paw swelling, polyarthritis index, and histological morphological of collagen-induced arthritis (CIA) rats, the antiinflammatory and immunoregulation activity between CP-25 and TGP or Pae was compared on the models of CIA.To study the effect of CP-25 on peritoneal macrophage (PM) (TNF-α, IL1, PGE2) from rats of adjuvant-induced CIA.