环境响应性高分子-多肽接合物材料的制备、表征及应用

来源 :第八届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户：zhufeng19791123

【摘要】

：

环境响应性聚合物,又称为智能聚合物,能够对外界环境中的微小刺激信号[1](温度、pH及离子强度等)的变化产生快速响应,在物理化学性质上发生改变,因而被广泛应用于药物释放、

【作者】

：

葛瑞罗施中

【机构】

：

北京市生物加工过程重点实验室,北京化工大学生命科学与技术学院北京市朝阳区北三环东路15号53信箱,100029

【出处】

：

第八届全国化学生物学学术会议

【发表日期】

：

2013年9期

【关键词】

：

pH/温度响应材料多肽自组装水凝胶

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

环境响应性聚合物,又称为智能聚合物,能够对外界环境中的微小刺激信号[1](温度、pH及离子强度等)的变化产生快速响应,在物理化学性质上发生改变,因而被广泛应用于药物释放、组织工程、化学和生物传感器等方面.同时,多肽不但具有良好的生物相容性,而且可以通过自组装过程形成一定的纤维结构[2],这在生物医学材料方面具有巨大的应用潜力.

其他文献

FAD-Ubiquinone Mediated Electron Transfer in Yeast NADH-Ubiquinone Oxidoreductase Revealed using Ele

Electron transport chain, or the respiratory chain, transports the electron from metabolic process derived NADH to the oxygen molecules, and is the most importa

会议

Electron Transportype-Ⅱ NADH DehydrogenaseElectron Spin ResonancePower Satura

Design, synthesis and biological evaluation of Thiazolo[3,2-a]pyrimidin-3-one derivatives as novel i

Staphylococcus epidermidis has become a significant pathogen causing infections due to biofilm formation on surfaces of indwelling medical devices.Biofilms asso

会议

thiazolo[32-a]pyrimidin-3-oneantibacterial activityantibiofilm activitystaph

阳离子端基肽类脂基因载体的合成

阳离子脂质体作为一种重要的非病毒基因载体,具有一定细胞毒性的缺点,在基因转运方面具有广阔的应用前景.选用脂质体DOTAP和Lipofectamine 2000为基因载体,考察其粒径、Zeta

会议

阳离子脂质体脂质体/DNA复合物基因转运细胞毒性

A G-quadruplex converts wild-type SOD1 into fibrillar aggregates under acidic conditions

Our previous studies suggest that different forms of DNA could act as an accelerating template in the wild-type Cu/Zn superoxide dismutase (wtSOD1) aggregation.

会议

SOD1 aggregationnucleic acidsG-quadruplexfibrilcytotoxicity

Synthesis and DNA-cleaving activities of berberine-based metal complexes

During the past decades, considerable interest has been attracted in transition metal complexes that are capable of binding and cleaving DNA under physiological

会议

Metal complexberberinesynthesisDNA cleavage

Probing Spontaneous Base Flipping of A Single-Mismatched Base Pair in Double-Stranded DNA

Many DNA base repairs and modifications, such as DNA methylation/demethylation, deamination, and hydroxylation, are known to occur extrahelically with the targe

会议

DynamicsSpontaneous single base flippingddFCS

基因编码非天然氨基酸扩展荧光蛋白发色团

通过扩展基因密码子,实现了具有金属结合能力的非天然氨基酸8-羟基喹啉丙氨酸(HqAla)(Cu2+ KD=0.1 fM)在活细胞中的编码.在sfGFP,sfYFP,PsmOrange及eqFP650荧光蛋白的发色团

会议

基因编码非天然氨基酸HqAla荧光蛋白发色团扩展

Enzymatic mechanism studies of C-O bond broken with the approach of isotopic labeled probes

Isoprenoids, the most structurally and functionally diverse group of metabolites with more than 50,000 members in nature, are constructed from two precursors, i

会议

DXP pathwayC-O bond brokenisotopic labeled probes

The key roles of 5Ile in the binding of fipronil with GABAA receptors from fruitfly and zebrafish, r

Fipronil, which act on insect GABAA receptor was an important insecticide for crop protection.However, the observed high toxicity on fish deeply limited its app

会议

GABAA receptorFipronilMolecular dynamics simulation

New Sight into DegPs Role in Protein Quality Control

The heat-shock protein DegP is essential for the survival of Escherichia coli cells at elevated temperatures.Substrate binding transforms hexameric DegP into la

会议

ProteaseChaperoneProtein quality controlSingle molecule FRET

环境响应性高分子-多肽接合物材料的制备、表征及应用

其他学术论文