Probing Spontaneous Base Flipping of A Single-Mismatched Base Pair in Double-Stranded DNA

来源 :第八届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户：huwenrou

【摘要】

：

Many DNA base repairs and modifications, such as DNA methylation/demethylation, deamination, and hydroxylation, are known to occur extrahelically with the targe

【作者】

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Yandong Yin Lijiang Yang Guanqun Zheng Chan Gu Chengqi Yi Chuan He Yiqin Gao Xin-Sheng Zhao

【机构】

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BeijingNationalLaboratoryforMolecularSciences,PekingUniversity,Beijing100871,China;StateKeyLaborator

【出处】

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第八届全国化学生物学学术会议

【发表日期】

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2013年9期

【关键词】

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Dynamics Spontaneous single base flipping ddFCS

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Many DNA base repairs and modifications, such as DNA methylation/demethylation, deamination, and hydroxylation, are known to occur extrahelically with the target base flipped out of the DNA duplex.How these bases flip out of the DNA duplex, however, is still unknown (Figure A).

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Probing Spontaneous Base Flipping of A Single-Mismatched Base Pair in Double-Stranded DNA

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