Structure-Activity Relationships of Saponin derivatives:a Series of Entry Inhibitors for Highly Path

• 作 者: NingDing[1]QingChen[2]SumeiRen[1]YingGuo[2]YingxiaLi[1]
• 机 构: Department of Medicinal Chemistry,School of Pharmacy,Fudan University,826 Zhangheng Road,Shanghai 20
• 出 处: 第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
• 发表日期: 2012年期

　　The occurrence of highly pathogenic avian influenza virus H5N1 highlights the urgent need for new classes of antiviral drugs.Theoretically,each of steps in influenza viral life cycle can be a target of antiviral therapeutics.However,up to date,no licenced entry inhibitor drug is available for H5N1 or any other influenza viruses.