【摘 要】
：
The formation of glycosidic bond with stereoselectivity is a challenge in synthesis of oligosaccharides.D-glucose is the most abundant carbohydrate found in
【机 构】
：
School of Pharmacy,College of Medicine,National Taiwan University,Taipei 100
【出 处】
：
第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
The formation of glycosidic bond with stereoselectivity is a challenge in synthesis of oligosaccharides.D-glucose is the most abundant carbohydrate found in nature,which is composed of wide variety of biologically potent structures,including glycoproteins and glycolipids.Thus,developing a method for synthesis of α-or β-glycoside is essential in carbohydrate chemistry.In β-glycosidic bond formation,neighboring group participation by 2-O-carboxylate ester is a reliable strategy.However,these strategies usually suffer from several side reactions,such as C2 acyl migration,aglycan transfer reaction.This ester-type protective groups are usually basic liable which make them difficult to be orthogonal deprotection.Herein we introduce a new protective group,2-O-carbamate,which can tolerate to strong acid,moderate base and can be removed by catalytic reduction.Accordingly,we present a versatile approach for β-glycosidic bond generation.
其他文献
让我们看看2001年高入技供应链发生的事故:思科系统因为对外判的承包商管理不善,必须要把价值2500亿的多余存货撇帐.Micron科技公司从收入里撇除32%或是等同2亿6000万的存货.
在日常生活中,因进食、服药、玩耍等原因,不慎将异物吸入气管的事情时有发生。由于事发突然,又十分危急,掌握家庭急救方法是十分必要的。
In daily life, due to eating, ta
Cathepsin E(cath E) is an intracellular aspartic protease that is mainly present in the immune system.Cath E is highly homologous to the analogous aspartic
在市场竞争日趋激烈的今天,企业高度重视品牌的打造和推广,而提高消费者忠诚度是品牌的打造和推广中一个非常重要的环节。忠诚度是影响消费者购买行为的关键因素,同时,也决定
箱涵是指洞身主要以钢筋混凝土的箱型管节修建的涵洞。箱涵由一个或者多个方形、矩形断面组成,一般都是由钢筋混凝土或者圬工制成的,在施工过程中钢筋混凝土相对应用面广点,
方正县位于黑龙江省中南部,长白山支脉张广才岭西北麓,蚂蜓河下游。其版图形同一把弯尺,横陈于松花江中游南岸。这里三面环山,一面临水,素称“八山半水分半田”。境内群峰竞
An alarming increment in pathogenic resistance to existing first line standard drugs is a serious problem in antimicrobial cure and necessitates continuing
Cordycepin is an important bioactive component of a Chinese traditional fungal drug,Cordyceps militeris(L.) Link.and has good hypolipidemic activity,possibl
日前,报上公布了1995年国家级科学进步奖评奖结果,现任巨龙公司总裁的邬江兴教授和他的同事们,在邮电工业总公司与解放军信息工程学院组织开发和国家科委、国家经贸委等部门
Increasing antibiotic resistance of bacterial pathogens has been observed for many years,both in Gram-negative and Gram-positive bacteria,concerning the iso