• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. TDI通过PI3K通路下调气道上皮粘附连接分子β-catenin的表达

TDI通过PI3K通路下调气道上皮粘附连接分子β-catenin的表达

来源 :中华医学会2014年全国变态反应学术会议 | 被引量 : 0次 | 上传用户：z7228279
【摘 要】
：
目的 甲苯二异氰酸酯(TDI)是最常见的职业性哮喘的致病因素之一,TDI哮喘约占成年人哮喘的9％-15％.TDI哮喘具有与过敏性哮喘相似的临床特征,但其确切机制尚有待于进一步阐明.我们前期已经在体内外证明TDI可以引起气道上皮细胞屏障功能破坏,本研究进一步探讨TDI对哮喘气道上皮粘附连接分子破坏的分子机制.方法 按既往建立的方法建立TDI哮喘模型.评价LY294002处理后对气道炎症,气道反应性及
【作 者】
：
姚利红 赵海金 唐海雄 宋甲富 董航明 邹飞 蔡绍曦 
【机 构】
：
南方医科大学南方医院呼吸与危重症医学科,慢性气道疾病实验室 南方医科大学南方医院公共卫生与热带医学
【出 处】
：
中华医学会2014年全国变态反应学术会议
【发表日期】
：
2014年3期
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
目的 甲苯二异氰酸酯(TDI)是最常见的职业性哮喘的致病因素之一,TDI哮喘约占成年人哮喘的9％-15％.TDI哮喘具有与过敏性哮喘相似的临床特征,但其确切机制尚有待于进一步阐明.我们前期已经在体内外证明TDI可以引起气道上皮细胞屏障功能破坏,本研究进一步探讨TDI对哮喘气道上皮粘附连接分子破坏的分子机制.方法 按既往建立的方法建立TDI哮喘模型.评价LY294002处理后对气道炎症,气道反应性及粘附连接分子的影响.
其他文献
Preconditioning via angiotensin type 2 receptor activation improves therapeutic efficacy of bone mar
Background The therapeutic efficiency of bone marrow mononuclear cells (BMMNCs) autologous transplantation for myocardial infarction (MI) remains low.Here we developed a novel strategy to improve card
会议
MicroRNA-15b enhances hypoxia/reoxygenation-induced apoptosis of cardiomyocytes via a mitochondrial
Background Myocardial ischemia reperfusion (I/R) can induce altered expression of microRNAs (miRNAs).The miRNAs-miR-15a,miR-15b and miR-16 have been shown to play a role in apoptosis,although not in c
会议
Hypoxia pretreatment mesenchymal stem cells inhibit hypoxia induced cardiac fibroblast activation vi
Background Activation of cardiac fibroblasts (CFs) and their differentiation into myofibroblasts (MCFs) is a crucial event in the progression of cardiac fibrosis after myocardial infarction that leads
会议
SIRT1 enhances therapeutic efficacy of aged mesenchymal stem cells in rat myocardial infarction via
Background Mesenchymal stem cells (MSCs) hold great promise for stem cell therapy and are gradually used in clinical trials in recent years.However,advanced age is a negative factor for autologous MSC
会议
Expression and signifigance of bone marrow mesenchymal stem cells transfected with different proport
Background We adopt the lentiv-GFP,carrying green fluorescent,as a vector to study the characteristics of the pacemaker current in the MSCs co-transfected with different proportions of hHCN1 and hHCN4
会议
Angiotensin Ⅱ type 1 receptor mediates cardiomyocyte autophagy induced by angiotensin Ⅱ through p38
Background Autophagy plays an important role in the development of angiotensin Ⅱ (Ang Ⅱ)-induced cardiac remodeling.However,the mechanism has not been completely understood.This study is designated to
会议
Targeted cell engraftment into infarcted myocardium by retrograde coronary venous infusion of bone m
Background Cell transplantation has emerged as a promising treatment for cardiac repair after myocardial infarction.However,efficient cell delivery to the targeted myocardium remains a practical chall
会议
Combined delivery of basic fibroblast growth factor and bone marrow mesenchymal stem cells via coron
Background Retrograde coronary venous delivery of basic fibroblast growth factor (bFGF) or bone marrow mesenchymal stem cells (MSCs) have been demonstrated to target infarcted myocardium.The present s
会议
Molecular imaging of atherosclerotic plaque characteristics via profilin-1 antibody labeled PEI-Fe3O
Background Atherosclerosis and its complications are the major cause of mortality all over the world.It is reported recently that profilin-1,an intracellular actinbinding protein,plays a pivotal role
会议
户尘螨特异性免疫治疗不同给药途径后支气管哮喘患儿体内调节性T细胞水平变化
目的 支气管哮喘是严重威胁儿童生命健康的一种慢性呼吸道疾病,目前特异性免疫治疗被认为是唯一针对病因的治疗方法,近年来随着变应原试剂的标准化及治疗途径的多样化,其治疗的安全性及有效性越来越受到人们的重视.本研究通过比较经不同给药途径进行户尘螨特异性免疫治疗后患儿体内调节性T细胞的水平变化,旨在一定程度上为阐明特异性免疫治疗的临床免疫学机制以及评价其远期治疗效果提供依据.方法 收集2012年2月至20
会议