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Background Myocardial ischemia reperfusion (I/R) can induce altered expression of microRNAs (miRNAs).The miRNAs-miR-15a,miR-15b and miR-16 have been shown to play a role in apoptosis,although not in cardiac-related models.We investigated the roles of miR-15b in hypoxia/reoxygenation (H/R)-induced apoptosis of cardiomyocytes.