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Objective: To assess the therapeutic strategies and prognostic factors that could influence the clinical outcome of hilar cholangiocarcinoma.Methods: A total of 215 of hilar cholangiocarcinoma patients undergoing resection from January 1990 to December 2009 were included in this study.Survival and follow-up were calculated from the date of initial histologic diagnosis to the dates of the first recurrence or death and last contact, respectively.Univariate and multivariate analyses were performed to examine the factors affecting clinical outcome and recurrence.